Cannabinoid decreased pain without producing tolerance or dependence

Slivicki, Richard A., et al. "Positive allosteric modulation of cannabinoid receptor type 1 suppresses pathological pain without producing tolerance or dependence." Biological psychiatry 84.10 (2018): 722-733.

Despite increasing evidence of cannabinoids’ analgesic properties, concerns regarding its potential for abuse limit its utility in pain management. The present study posits a solution to such valid and thoughtful concern. GAT211 is a novel compound that positively acts on CB1 receptors to decrease pain. Unlike other cannabinoids, treatment with GAT211 did not produce tolerance or dependence despite alleviating pain.

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